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Psychoactive drug restrictions and prohibitions have typically followed a reactionary pattern. From tobacco to LSD, the introduction of novel drugs has prompted therapeutic experimentation. Officials showed little concern until these substances also became popular recreational intoxicants.

In Madness, Cannabis and Colonialism, James H. Mills examines the lunatic asylums of colonial India, between the war of 1857 and the end of the nineteenth century. Throughout this period, the total number of mental patients in the country did not exceed five thousand at any given time.